Effectiveness of Ethanol Gel and Essential Oil of Kencur Rhizome (Kaempferia galanga L.) base Karbopol against Propionibacterium acnes
DOI:
https://doi.org/10.25134/quagga.v16i1.81Keywords:
kencur rhizome, carbopol, gel, Propionibacterium acnesAbstract
Kencur rhizome (Kaempferia galanga L.) is an aromatic herbal plant as antibacterial and anti-inflammatory. This study aims to determine the physical quality and effectiveness of gel preparations of ethanol extract and essential oil of kencur rhizome based on carbopol inhibiting Propionibacterium acnes bacteria. This study used a Randomized Block Design (RAL) with 2 different treatments of 5 levels each, namely ethanol extract gel treatment and essential oil extract gel with concentrations of 10%, 20%, 30%, 40% and 50%. The results of the gel formulation of extracts and essential oils based on carbopol showed pH, texture, spreadability and adhesiveness according to the quality standards of topical preparations. The antibacterial inhibition of the gel was moderate at 50% extract concentration (11.41 mm); and 50% essential oil (9.04 mm). Positive control treatment inhibited growth by 15.84 mm while negative control showed no response. The extract gel and essential oil of galangal rhizome had a significant effect but were less effective in inhibiting P. acnes bacteria. Adding the maximum concentration of extract and essential oil can optimize acne healing.
References
Afifi, R., Erlin, E., Rachmawati, J., & Erlin, R. 2018. Anti-bacterial test of star fruit leaf extract Uji anti bakteri ekstrak daun belimbing wuluh (Averrhoa bilimbi L.) terhadap zona hambat bakteri jerawat Propionibacterium acnes secara in vitro. Quagga: Jurnal Pendidikan dan Biologi. 10(1):10-17.
Agustiani, F. R. T., Sjahid, L. R., &; Nursal, F. K. 2022. Kajian literatur : peranan: berbagai jenis polimer sebagai gelling agent terhadap sifat fisik sediaan gel. Majalah Farmasetika. 7(4): 270-287.
Alnabati, N. A., Al-hejin, A. M., Noor, S. O., Ahmed, M. M. M., Abu-zeid, M., Mleeh, N. T., Ahmad, N., Al-hejin, A. M., & Omar, S. 2021. The antibacterial activity of four Saudi medicinal plants against clinical isolates of Propionibacterium acnes. Biotechnology & Biotechnological Equipment.35(1):415-424.
Alvionida, F., Sulistyani, N., & Sugihartini, N. 2021. Composition of carbopol 940 and HPMC affects antibacterial activity of beluntas (Pluchea indica (L.)) leaves extract gel. Pharmaciana, 11(3): 427-438.
Anggraini, M., Ayu, G., & Saputri, R. 2021. Comparison of moisture content and condition of essensial oil on rhizome kencur (Kaempferia galanga L.) with different drying treatment. Jurnal Analis Farmasi. 6(2): 79-83.
Arsa, A. K., &; Achmad, Z. 2020. E Ekstraksi minyak atsiri dari rimpang temu ireng (Curcuma aeruginosa Rox) dengan pelarut etanol dan n-heksana. Jurnal Teknologi Technoscientia, 13(1): 83-94.
Cendana, Y., Adrianta, K. A., &; Suena, N. M. D. S. 2021. Formulasi spray gel minyak atsiri kayu cendana (Santalum album L.). Jurnal Ilmiah Medicamento, 7(2): 84-89.
Chilicka, K., Rogowska, A. M. Szygula, R. 2021. Effects of topical hydrogen purification on skin parameters and acne vulgaris in adult women. In Healthcare: Multidisciplinary Digital Publishing Institute. 9(2): 1-14.
Dreno, B., Bagatin, E., Blume-Peytavi, U. Rocha, M & Gollnick, H. 2018. Female type of adult acne : physiological and psychological considerations and management. JDDG : Journal der Deutschen Dermatologischen Gesellschaft. 16(10): 1185-1194.
Dreno, B., Bordet, C., Seite, S., & Taieb, C. 2019. Acne relapses : impact on quality of life and productivity. Journal of the European Academy of Dermatology and Venereology. 33(5): 937-943
Febriyanto, G. 2022. Efektivitas antibakteri minyak atsiri rimpang kencur ( Kaempferia galanga L .) terhadap bakteri penyebab penyakit gigi dan mulut. Jurnal Kesehatan Tambusai. 3(4): 685-691.
Hari, R., Fajar S., H., Apriliyanti, I. P., & Jember, A. F. 2018. Evaluasi sifat fisik dan uji iritasi gel ekstrak kulit buah pisang (Musa acuminata Colla). Journal of Current Pharmaceutical Sciences. 2(1): 131–135.
Hasanah, N., &; Novian, D. R. 2020. Analisis ekstrak etanol buah labu kuning (Cucurbita moschata D.). Jurnal Ilmiah Farmasi, 9(1): 54-59.
Irianto, I. D. K., Purwanto, P., &; Mardan, M. T. 2020. Aktivitas antibakteri dan uji sifat fisik sediaan gel dekokta sirih hijau (Piper betle L.) sebagai alternatif pengobatan mastitis sapi. Majalah Farmaseutik, 16(2): 202-210.
Julianti, P. A., Hutahean, T. A., &; Februyani, N. 2023. Formulasi sediaan gel antiacne ekstrak daun sirih (Piper betle L.) sebagai alternatif terapi acne vulgaris terhadap bakteri Propionibacterium acnes secara in vitro. Indonesian Journal of Health Science. 3(2a): 308-319.
Kemenkes RI (Kementerian Kesehatan Republik Indonesia). 2017. I Farmakope Herbal Indonesia. Edisi II. Hal : 209.
Khairullah, A. R., Solikhah, T. I., Nur, A., Ansori, M., & Hanisia, R. H. 2021. Medicinal importance of Kaempferia galanga L. (Zingiberaceae) : A comprehensive review. Journal of Herbmed Pharmacology. 10(3): 281-288.
Kumar, A. 2020. Phytochemistry, pharmacological activities and uses of traditional medicinal plant Kaempferia galanga L. An overview. Journal of Ethnopharmacology. 253(2020): 1-19.
Lewa, S., Hidayat, M &; Triana, E. 2023. Formulasi dan evaluasi karakteristik fisik sediaan masker gel peel off menggunakan ekstrak etanol daun jambu mente (Annacardium ocidenta Linn). FAJR : Jurnal Riset Kefarmasian. 1(2): 6-14.
Primawati, S. N., &; Jannah, H. 2019. Pengaruh metode ekstraksi kencur (Kaempferia galanga L.) terhadap pertumbuhan Staphylococcus aureus. Bioscientist : Jurnal Ilmiah Biologi, 7(2): 177-181.
Putri, N. F. A., Nawangsari, D., &; Sunarti, S. 2021. Formulasi sediaan gel scrub wajah serbuk biji kopi arabika (Coffee arabica) dengan konsentrasi karbopol 940 sebagai gelling agent. Jurnal Farmasi & Sains Indonesia. 4(2): 68-73.
Rasyid, A. U. M., & Amody, Z. 2020. Pengujian efektifitas formula gel ekstrak daun beluntas (Pluchea indica (L.) Less) dengan variasi konsentrasi gelling agent sebagai kandidat sediaan anti jerawat. Jurnal Ilmiah Manuntung. 6(2): 312-322.
Rohman, M. D. Q., Setiawan, I., &; Nirvana, A. P. 2020. Optimasi HPMC dan karbopol dalam formulasi sediaan gel antiseptik ekstrak etanol daun beluntas dan aktivitas antibakteri terhadap Staphylococcus aureus. Jurnal Insan Farmasi Indonesia. 3(2): 327-336.
Rostikawati, R. T. 2021. Uji antibakteri obat kumur ekstrak etanol tanaman ciplukan (Physalis angulata L) terhadap bakteri gram positif. Quagga : Jurnal Pendidikan dan Biologi. 13(1): 103–107.
Safitri, F. I., Nawangsari, D., & Febrina, D. 2021. Overview : Application of carbopol 940 in gel. In International Conference on Health and Medical Sciences (AHMS 2020) Atlantis Press. pp: 80-84.
Samodra, G., & Febrina, D. (2020). The Comparison Between Anti-Inflammatory Effects of Ethanol Extract from Kaempferia galanga L. and Diclofenac Sodium Induced by Carrageenan. 20(Icch 2019), 18–22.
Sari, R. P., Harnis, Z. E., & Harahap, N. I. 2022. Phytochemical screening and formulation of hand sanitizer gel preparations from temu hitam rhizome extract (Curcuma aeruginosa Roxb). International Journal of Science, Technology & Management. 3(6): 1812-1819.
Silalahi, M. 2019. Kencur (Kaempferia galanga) dan bioaktivitasnya. Jurnal Pendidikan Informatika dan Sains, 8(1): 127-142.
Song, L., Wu, X., Xie, J., Zhang, H., Yang, H., Zeng, Q., Yang, X., Xie, W., & Linn, K. 2021. Kaempferia galanga Linn. Extract – a potential antibacterial agent for preservation of poultry products. LWT. 147(111553): 1-11.
Srivastava, N., Singh, S., Chand, A., & Shanker, K. 2019. Aromatic ginger (Kaempferia galanga L .) extracts with ameliorative and protective potential as a functional food, beyond its flavor and nutritional benefits. Toxicology Reports. 6(1):521-528.
Subaryanti, S., Triadiati, T., Sulistyaningsih, Y. C., & Pradono, D. I. 2022. Total phenol content of accessions of kencur (Kaempferia galanga L.) at different altitudes. Natural Science: Journal of Science and Technology. 11(1): 1-6.
Wahyuni, I. S., Sufiawati, I., Nittayananta, W., & Levita, J. 2022. Anti-inflammatory activity and wound healing effect of Kaempferia galanga L. rhizome on the chemical-induced oral mucosal ulcer in wistar rats. Journal of Inflammation Research. 15: 2281–2294.
Wang, S., Zhao, H., Xu, H., Han, X., & Wu, Y. 2021. Kaempferia galanga L.: progresses in phytochemistry, pharmacology, toxicology and ethnomedicinal uses. Frontiers of Pharmacology. 12(10): 1-17.
Yao, F., Zhu, X., Wang, Y., & He, X. 2018. Phenolics from the rhizomes of Kaempferia galanga L. and their antioxidant activity. Journal of Complementary and Alternative Medical Research. 5(1): 1-6.
